Weinberg's Lab - LipidRescue

LipidRescue Experiments

Older LipidRescue Experiments (rat) Showing Effects of Early and Late Treatment Arterial and ECG Traces of Actual Experiments
- Lipid Given Early In this experiment, a 4 mL/kg bolus of 20% lipid was given approximately one minute after bupivacaine induced asystole (15 mg/kg bupivacaine given iv over 30 sec). The lipid bolus was repeated once approximately 5 minutes later and an infusion started.
- Lipid Given Late (20 minutes downtime) A control experiment, converted after 20 min unsuccessful resuscitation to a lipid treatment.
Newer LipidRescue Experiments Comparing Lipid with Saline and "No-Treatment' This is a group of three experiments on anesthetized rats. Each recieves a large bolus of bupivacaine, then in addition to ventilation with 100% oxygen and chest compressions are given one of three iv treatments: nothing, saline or lipid emulsion.
- No Intravenous Treatment There is minimal recovery of hemodynamics over several minutes of resuscitation. This is a 'no-treatment' control. Note the audio commentary.
- Saline Treatment This experiment controls for the effects of volume on recovery from bupivacaine overdose. There is minimal hemodynamic recovery.
- LipidRescue This subject received lipid emulsion in addition to chest compressions and ventilation with 100% oxygen. Recovery is complete by four minutes. Note the audio commentary.